Oolong Tea Polyphenols–Phospholipids Complex Reduces Obesity in High Fat Diet‐Induced Mice Model

Abstract

In this study, the anti‐obesity effect of oolong tea polyphenols–phospholipids complex (OTC) was investigated. OTC was prepared with oolong tea polyphenols (OTP) and phospholipids, and exhibited higher stability than OTP in vitro. Then high fat diet‐induced obesity human flora‐associated (HFA) mice model were obtained, and the administration of both OTP and OTC alleviated the changes of the serum and liver levels induced by high fat diet dramatically. The numbers (log10 cell mL−1) of Bifidobacterium and Lactobacillus/Enterococcus spp., Bacteroides‐Prevotella and Clostridium histolyticum in obesity models fed with OTC after 8 weeks were 8.28 ± 0.03, 8.21 ± 0.01, 7.23 ± 0.02, and 7.05 ± 0.03 compared with 8.21 ± 0.02, 8.07 ± 0.02, 7.31 ± 0.02, and 7.10 ± 0.01, respectively, in the control. Together, it confirmed the potential of phospholipids in the promotion of intestinal transport of polyphenols, suggesting OTC may have prebiotic‐like activity to prevent obesity‐related metabolic disorders.Oolong tea polyphenols–phospholipids complex show modulatory effect on the intestinal microbiota of high fat diet‐induced obesity mice model, and may have prebiotic‐like activity contributing to the prevention of obesity.