Oocyte retrieval rate through repeated identical controlled ovarian stimulation cycles in donors.

Abstract

Objective: To assess whether repetitive controlled ovarian stimulation (COS) cycles may alter the ovarian response in oocyte donors. Design: Retrospective study in a private reproductive medicine clinic. Materials/Methods: Seventy-seven young, healthy women aged 18 to 35 years with two or more cycles with an identical COS, as for number of stimulation days; type and doses of analogue used; type and daily doses of gonadotrophins, were studied. Eighteen of them underwent three identical COS cycles. An intragroup ANOVA was used to compare outcomes in the same woman through the repeated cycles. Results: In the group of 77 donors who underwent two COS cycles, mean age ± SD was 25,1 ± 4,5 and 25,6 ± 4,4 years for the first and second cycle respectively. Gonadotrophins were administered for 9,5 ± 1 day (mean ± SD), using 1934 ± 722 UI of FSH. 19,4 ± 7,7 oocytes were retrieved in the first cycle, and 18,7 ± 6,4 in the second. Immature oocytes were 0,7 ± 1,6 and 0,8 ± 2,2 for the first and second cycle, respectively. Atresic oocytes were 0,2 ± 0,5 and 0,007 ± 0,3. Values for the group who had three cycles are shown in Table 1. No differences were found in the number of mature oocytes, neither in immature or atresic oocytes, in two or three identical COS cycles.Table 1COS characteristics in donors with 3 cycles (n = 18).Cycle 1Cycle 2Cycle 3Donor ageamean ± SD.24,8 ± 4,425,2 ± 4,425,7 ± 4,3Days of gonadotrophin administrationamean ± SD.9,7 ± 0,69,7 ± 0,69,7 ± 0,6Doses of FSH (in IU)amean ± SD.1920 ± 5401920 ± 5401920 ± 540Retrieved mature oocytesamean ± SD., bp ≥ 0,84.20,2 ± 6,819,3 ± 6,819,6 ± 8,7Retrieved immature oocytesamean ± SD., cp ≥0,73.0,6 ± 1,41,2 ± 4,01,2 ± 2,9Retrieved atresic oocytesamean ± SD., dp ≥ 0,22.0,2 ± 0,50,005 ± 0,20,4 ± 0,9a mean ± SD.b p ≥ 0,84.c p ≥0,73.d p ≥ 0,22. Open table in a new tab Conclusions: Retrieved oocyte rate in young, healthy voluntary donors is maintained through repeated COS cycles. This suggests that successive stimulation cycles do not impair ovarian response in this selected group of women.