Oocyte Cryopreservation: Retrospective Analysis Of 5 Years Experience

Halime Goktepe,Gulsen Dogan Durdag,Batuhan Ozmen,Esengul Turkyilmaz,Murat Sonmezer,Cem Atabekoglu

doi:10.21613/gorm.2019.1014

Halime Goktepe, Gulsen Dogan Durdag + Show 4 more

Open Access

https://doi.org/10.21613/gorm.2019.1014

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Abstract

OBJECTIVE: To analyze demographic and clinical data of patients who resorted to oocyte freezing between January 2014 and December 2018. STUDY DESIGN: Patients who applied to the Reproductive Endocrinology and Infertility Unit of Ankara University School of Medicine between January 2014 and December 2018 with the request of oocyte freezing were included in this study. The files and computer records of the patients were analyzed retrospectively and sociodemographic, clinical and laboratory data were evaluated. RESULTS: A total of 46 cycles were recorded in 40 patients over a 5-year period. The main indications were low ovarian reserve and/or advanced age (68.3%) and malignancy diagnosis (31.7%). There was a significant difference between elective fertility preservation and oncofertility preservation (Onco-FP) groups in terms of the age (38.4±4.7 vs 28.4±6.1; p=0.001). There was a significant difference between two groups in favor of oncofertility group in terms of anti-Mullerian hormone level, basal follicle-stimulating hormone level, antral follicle count, trigger day estradiol (E2) level, number of obtained oocytes, MII oocytes, and frozen oocytesCONCLUSION: According to our study, the most prominent oocyte cryopreservation indication was advanced age and/or low ovarian reserve. The number of oocytes collected from patients in the Onco-FP group and thus the number of frozen oocytes was significantly higher than in the elective fertility preservation group, due to younger ages and better ovarian reserve in the Onco-FP group. Abdominal administration of the technique is particularly important for virgin patients in our country. Oocyte freezing is a fertility protection method available in a wide range of indications for reproductive-aged women.

Highlights

Due to social reasons, delayed marriage to advanced years and the presence of patients diagnosed with cancer, the desire to preserve fertility is increasing.Ovarian capacity and fertility decrease with age in women
The number of oocytes collected from patients in the Onco-FP group and the number of frozen oocytes was significantly higher than in the elective fertility preservation group, due to younger ages and better ovarian reserve in the Onco-FP group
We aimed to evaluate sociodemographic, clinical and laboratory characteristics of patients undergoing oocyte cryopreservation in our center

Summary

Introduction

Due to social reasons, delayed marriage to advanced years and the presence of patients diagnosed with cancer, the desire to preserve fertility is increasing. Ovarian capacity and fertility decrease with age in women. This has led to a new approach in the world called “social egg freezing”. With the improvements in cancer treatment, oocyte freezing has gained importance for patients who are diagnosed with cancer at an early age and desire to maintain fertility. Other factors that reduce fertility include having a poor ovarian reserve, a history of early menopause in the family, systemic disease (Systemic lupus erythematosus, rheumatoid arthritis groups) that have to be put on lifelong immunosuppression and having advanced stage endometriosis that requires oophorectomy and disrupts the quality of life [1,2]. Fertility protection procedures are prominent for this group of patients

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