Abstract
Two systemic injections of 6-hydroxydopamine (6-OHDA) on the first day of life caused transient elevations of spinal dopamine and serotonin but permanent depletion of norepinephrine. In untreated rats, the spinal concentrations of these amines peaked at 10, 15 and 20 days respectively. 6-Hydroxydopamine abolished decapitation convulsions during adult-hood but the convulsion latency and duration were normal at 20 days of age. These data are consistent with others suggesting maturation of aspects of seizure manifestations at around 20 days. The tonic-clonic aspects of seizures may consist of an early maturing trigger involving spinal noradrenergic projections from the locus cocruleus and a later maturing modulator involving spinal serotonergic neurones.
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