Abstract
Plasma Adiol-G values, considered as a good marker of peripheral androgen conversion in adults, have not yet been reported in children. Adiol-G was measured in plasma aqueous phase left after ether extraction of unconjugated steroids. The method included β-glucuronldase hydrolysis, ether extraction, celite column Chromatography and specific RIA. The results, in 150 normal children and 33 adults, are given in ng/dl (mean±SD). In adults, Adiol-G levels were significantly higher (p <0.001) in males (436±171) than in females (135±74). In children 1-6 years old, Adiol-G was low without sex difference: 21.2±9.8 in boys, 19.9±6.6 in girls. Then, Adiol-G levels rose progressively: 43.9±13.8 In boys and 47.8±18 in girls 9-11 years old. After the age of 11, Adiol-G rose significantly and more rapidly in boys than in girls: 72.7±39 in boys vs 52.9±17 in girls from 11 to 13 years and 158.8±68 in boys vs 76±4.8 in girls from 13 to 15 years. Adult values were observed at age 15-16 in girls, while in boys, Adiol-G levels continued to rise till adulthood. In 3 boys, age 13.6 to 19, with complete adrenal insufficiency and normal pubertal development, values of Adiol-G were normal for age. The Adiol-G rise observed at the end of an hCG test (204±159) in 12 boys (1-11 yrs) and the high values found in untreated CAH, 528±267 in 12 infants and 216.6±102 in 7 girls (1-6 yrs) suggest that Adiol-G could be used as a parameter of androgen metabolism in childhood.
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