Abstract
Methods: The contribution of tramadol (M), O-demethyl (M1, CYP2D6 mediated) tramadol and N-demethyl tramadol (M2, CYP3A4 mediated) to overall tramadol elimination and the log M/M2 were assessed in 24 hours urine collections during continuous intravenous tramadol administration and correlations with perinatal characteristics [postnatal age (PNA), postmenstrual age (PMA)] were investigated (1).
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