Abstract
The one-way mixed lymphocyte reaction of rat thymocytes to allogeneic cells was studied, using ACT and Fischer rat strains. Mitomycin-treated thymocytes or thymocytes from F 1-hybrid rats were used as the stimulating cells. The reactivity of neonatal rat thymus cells was somewhat lower than that of adult rat thymocytes, but was nevertheless quite significant. No reactivity could be determined in neonatal rat thymocytes to mitomycintreated xenogeneic (mouse) cells, although thymocytes from 7-day-old rats reacted equally well to allogeneic and xenogeneic cells. Graft-versus-host reactivity of both rat and mouse thymus cells was also determined. It was found that neonatal and adult rat thymocytes, as well as adult mouse thymocytes, could induce splenomegaly in neonatal mice, but not in neonatal rats. The implications of these findings are discussed in the light of recent theories linking reactivity to histocompatibility antigens to antibody formation.
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