Abstract
The activities of adenylcyclase (AC) and phosphodiesterase (PDE) were determined in cerebral cortex of rats of 1 day to 18 months of postnatal age. The activity of dopamine-sensitive and serotonin-sensitive adenylcyclase was also determined in young and old rat brain. AC increased with age and attained a maximum at about 12 weeks of life which plateaued down at 5 months and remained unchanged in the later stages of life. Similarly PDE increased upto 15 weeks which later attained plateau. Dopamine-sensitive AC was not different between young and old rats. However, serotonin-sensitive AC was significantly more in old rats than in young rats. The increase in AC and PDE activity with aging is not only due to increase in protein content but might also be due to increase in cells rich in these enzymes.
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