Abstract
The effects of endothelin-1 on tissue homeostasis in newborn and adult albino rats were studied by(3)H-thymidine autoradiography, staining with AgNO(3), computer-assisted morphometry, and biochemiluminescence. In adult rats the ability of endothelin-1 to activate DNA synthesis in epithelial cells decreased compared to that in newborn animals; inversion of the stimulatory effects of endothelin-1 on the nucleolar apparatus of cardiomyocytes and pronounced intensification of free radical oxidation in the heart were also seen in adult animals. These differences can be related to ontogenetic peculiarities of endothelin-1 reception.
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