Abstract
Changes in the content of four methylated basic amino acids (3-methylhistidine, N g,N g-dimethylarginine, monomethyllysine and trimethyllysine) in myosin of lower extremities in laboratory rodents (Wistar rats, golden hamsters and white mice) were followed. Material from animals aged 4, 6, 14 and 90 days and 1 and 2 yr as well as from foetuses was available by the time of the present study. 3-Methylhistidine in myosin hydrolysates from foetuses was absent. First trace amounts of this amino acid were observed in 6 days old baby animals regardless of the tested rodent species. The age-dependent increase in 3-methylhistidine content is about logarithmic. Similar trends were observed also with ε-N-monomethyllysine. First measurable amounts of this amino acid appeared shortly before delivery. The content of trimethyllysine increased up to the 14th day of the postnatal development. Thenafter its content in myosin hydrolysates declines. The highest content of N g,N g-dimethylarginine (unsym. DMA) was observed in the prenatal stage. Shortly after delivery, its content drops steeply down and last traces of this amino acid were observed at the age of 6 days.
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