Abstract

1. 1. The isozyme patterns of lactate dehydrogenase (LDH) and malate dehydrogenase (MDH) in heart, liver, kidney, skeletal muscle, brain and serum of the developing gerbil ( Meriones unguiculatus) were investigated. A comparison was made with the correspondig organs of mouse, rat and rabbit during their ontogenetic development. 2. 2. Significant developmental changes were found in the LDH isozyme pattern of heart and kidney of all four species, in the brain of gerbil, mouse and rat and in lie liver of the rabbit. The isozyme pattern of MDH did not change significantly during the ontogeny of the four species. 3. 3. The gerbil liver was shown to have only one LDH isozyme, LDH 5, at all developmental stages studied. 4. 4. An attempt was made to correlate the LDH/MDH quotients with the values of the percentage A-subunits and with the prevailing metabolism in the developing gerbil organs.

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