Abstract
The ontogenesis of the [ 3H]diazepam binding sites and their modulation by gamma-aminobutyric acid has been studied in rat brain cortex. Specific binding of [ 3H]diazepam (calculated in fmole per mg of wet weight of tissue) is 2% of adult binding level, when measured at 16 days of gestation, 20% at birth and reaches the adult levels approximately 3 weeks after birth. An increase in [ 3H]diazepam binding after the in vitro addition of GABA to the extensively washed rat brain membrane preparation was observed at each stage of development and was due to a change in affinity without significant alteration in the total number of [ 3H]diazepam binding sites. Furthermore, the gamma-aminobutyric acid effect was found to decrease with age.
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