Abstract
BackgroundCalcium carbonate antacids are potent over-the-counter antacids, made more effective by adding magnesium carbonate (as in Rennie, Bayer). However, published studies on their onset of action are scarce. Therefore, we carried out an in vitro study comparing Rennie and placebo under simulated conditions of the human stomach (artificial stomach model) to reconfirm the onset of action of Rennie.MethodsThe validated Simulator of the Human Intestinal Microbial Ecosystem apparatus (SHIME, ProDigest, Belgium) was used, comprising five reactors simulating different parts of the human gastrointestinal tract. Both Rennie and placebo were dosed at two tablets per incubation over six independent, 2-h stomach incubations each. Primary objectives: to evaluate the time required to achieve pH 3.0, 3.5, 4.0 and 4.5, as well as the maximum pH reached. Secondary objective: to evaluate pepsin activity over the entire 2-h gastric incubation.ResultsAfter addition of Rennie, the gastric medium reached a pH of 3.0 within 40 s. The maximum pH of 5.24 was maintained for almost 10 min. In contrast, the maximum pH with placebo was 1.28 during the entire gastric simulation. Furthermore, Rennie strongly reduced the activity of mucosa-damaging pepsin during the period of increased pH. With placebo, the lower pH resulted in consistently high loads of digested peptides, reflecting the high cumulative and instantaneous pepsin activity.ConclusionsNew data is a critical component in informed decision making. Our data confirm the high efficacy and fast onset of acid-neutralizing action of Rennie, which begins to work within seconds.
Highlights
Calcium carbonate antacids are potent over-the-counter antacids, made more effective by adding magnesium carbonate
Antacids have been widely used for many years for the symptomatic treatment of gastroesophageal reflux disease and mild, non-ulcer dyspepsia [1]
The system comprises a succession of five reactors simulating different parts of the human gastrointestinal tract (GIT) (Fig. 1) [3]
Summary
Calcium carbonate antacids are potent over-the-counter antacids, made more effective by adding magnesium carbonate (as in Rennie, Bayer). We carried out an in vitro study comparing Rennie and placebo under simulated conditions of the human stomach (artificial stomach model) to reconfirm the onset of action of Rennie. Antacids have been widely used for many years for the symptomatic treatment of gastroesophageal reflux disease and mild, non-ulcer dyspepsia [1]. We carried out an in vitro study comparing Rennie and placebo under simulated conditions of the human stomach. SHIME has been in extensive use for more than 25 years and has been validated using in vivo parameters. The system comprises a succession of five reactors simulating different parts of the human GIT (Fig. 1) [3]. The first two reactors simulate different steps in food uptake and digestion (stomach, small intestine), while the last three compartments simulate the ascending, transverse, and descending colon
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
