Abstract
IntroductionThe intraosseous (IO) route has become a popular method to gain access to the peripheral circulation in emergency situations. Despite little supporting data, it is generally believed that IO absorption is immediate and equivalent to the intravenous (IV) route. It is important to determine if rocuronium can effectively be administered by the IO route. The aim of the study was to determine and compare the onset and duration of rocuronium when administered via the IO and IV routes in a normovolemic pig model.MethodsWe recorded electromyographic (EMG) data following tibial IO and peripheral IV administration of rocuronium (1.2 mg/kg) in 10 swine weighing between 56 and 71 Kg. We transformed data were transformed to percent of baseline, determined onset and recovery characteristics.ResultsThe onset EMG-time profiles for IO and IV administration were very similar: tibial IO compared to IV administration did not statistically alter the onset of paralysis. The IO group took statistically longer than the IV group to return to 50 (p=0.042), 75 (p=0.034) and 95 (p=0.036) percent of baseline activity.ConclusionThe duration of effect is statistically longer after IO administration but is more of an academic interest than a clinical concern. The results of this study suggest that rocuronium can effectively be administered via the IO route without the need for dose adjustments.
Highlights
The intraosseous (IO) route has become a popular method to gain access to the peripheral circulation in emergency situations
The results of this study suggest that rocuronium can effectively be administered via the IO route without the need for dose adjustments. [West J Emerg Med. 2014;15(2):241–245.]
The route became popular in the 1940s, and the sternal puncture kit for bone marrow infusions was a common component of emergency medical supplies during World War II.[1,2]
Summary
The intraosseous (IO) route has become a popular method to gain access to the peripheral circulation in emergency situations. It is generally believed that IO absorption is immediate and equivalent to the intravenous (IV) route. It is important to determine if rocuronium can effectively be administered by the IO route. The route became popular in the 1940s, and the sternal puncture kit for bone marrow infusions was a common component of emergency medical supplies during World War II.[1,2] Following World War II, the use of IO devices began to diminish and was all but abandoned with the rapid development of plastic catheters and routine venous cannulation. It is generally believed that IO absorption is immediate and equivalent to the IV route. Pharmacokinetic evaluation of medications commonly used via Volume XV, no. 2 : March 2014
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
