Ononin Alleviates Sublesional Bone Loss and Inflammation Following Spinal Cord Injury in Rats by Regulating Adenosine 5′-Monophosphate-Activated Protein Kinase Signaling Pathway

Abstract

Inhibition of bone loss is one of the ways to alleviate motor dysfunction caused by spinal cord injury, a lifelong and lifechanging injury. Isoflavone from legumes that include ononin, Calycosin-7-O-β-Glucoside, and others have been shown to have potential for the treatment of orthopedic diseases. While there are potentials for ononin to improve the motor function of spinal cord injury, studies on the subject are lacking. To this end, we examined the ameliorative role of ononin in an animal model of spinal cord injury. Our results show the ononin reduced inflammatory response, decreased femoral bone loss, and promoted osteoblast formation in rats with spinal cord injury through promotion of adenosine 5′′-monophosphate-activated protein kinase signaling pathway.