Abstract
High-resolution FlowNMR was coupled to a continuous flow reactor to monitor polymer molecular weight evolution online by diffusion ordered NMR spectroscopy.
Highlights
High-resolution FlowNMR was coupled to a continuous flow reactor to monitor polymer molecular weight evolution online by diffusion ordered NMR spectroscopy
In this work we present the use of high-resolution FlowNMR spectroscopy for monitoring the progress of a polymerisation reaction in continuous flow mode
We have demonstrated the use of high-resolution FlowNMR spectroscopy for monitoring monomer conversion and molecular weight distributions of a growing polymer during a methyl acrylate reversible addition fragmentation chain transfer polymerization (RAFT) polymerization
Summary
High-resolution FlowNMR was coupled to a continuous flow reactor to monitor polymer molecular weight evolution online by diffusion ordered NMR spectroscopy. Obtaining molecular weight information in this manner is shown to be more accurate than classical SEC analysis at comparable measurement times, with relative errors around 5%. A good example for such approach is the CORSEMP system.[29] Rubens et al have demonstrated the use of a flow reactor coupled to SEC for machine-assisted synthesis, allowing for self-optimization of reaction conditions in order to produce target molecular weights with high fidelity.[1]
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