Abstract
Time-of-flight mass spectrometry (TOFMS) is coupled online with capillary electrophoresis (CE) to analyze mixtures of biomolecules using an electrospray ionization (ESI) interface. The eluent is electrosprayed directly from the CE capillary using a thin gold wire to maintain its potential. The ions are extracted at right angles to the initial direction of the ion beam, and a complete mass spectrum is recorded every 100 μs. This CE/ESI-TOFMS apparatus achieves a separation efficiency of 50 000 theoretical plates with a concentration detection limit of (1-2)×10 -6 molar, which corresponds to a mass detection limit of approximately 40-80 fmol per component
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