Abstract
BackgroundEarly evidence of COVID-19–associated coagulopathy disseminated rapidly online during the first months of 2020, followed by clinical debate about how best to manage thrombotic risks in these patients. The rapid online spread of case reports was followed by online interim guidelines, discussions, and worldwide online searches for further information. The impact of global online search trends and online discussion on local approaches to coagulopathy in patients with COVID-19 has not been studied.ObjectiveThe goal of this study was to investigate the relationship between online search trends using Google Trends and the rate of appropriate venous thromboembolism (VTE) prophylaxis and anticoagulation therapy in a cohort of patients with COVID-19 admitted to a tertiary hospital in Ireland.MethodsA retrospective audit of anticoagulation therapy and VTE prophylaxis among patients with COVID-19 who were admitted to a tertiary hospital was conducted between February 29 and May 31, 2020. Worldwide Google search trends of the term “COVID-19” and anticoagulation synonyms during this time period were determined and correlated against one another using a Spearman correlation. A P value of <.05 was considered significant, and analysis was completed using Prism, version 8 (GraphPad).ResultsA statistically significant Spearman correlation (P<.001, r=0.71) was found between the two data sets, showing an increase in VTE prophylaxis in patients with COVID-19 with increasing online searches worldwide. This represents a proxy for online searches and discussion, dissemination of information, and Google search trends relating to COVID-19 and clotting risk, in particular, which correlated with an increasing trend of providing thromboprophylaxis and anticoagulation therapy to patients with COVID-19 in our tertiary center.ConclusionsWe described a correlation of local change in clinical practice with worldwide online dialogue and digital search trends that influenced individual clinicians, prior to the publication of formal guidelines or a local quality-improvement intervention.
Highlights
Since late 2019, the knowledge of the clinical sequelae of COVID-19 has increased largely through the rapid dissemination of information through various information platforms
A statistically significant Spearman correlation (P
We described a correlation of local change in clinical practice with worldwide online dialogue and digital search trends that influenced individual clinicians, prior to the publication of formal guidelines or a local quality-improvement intervention
Summary
Since late 2019, the knowledge of the clinical sequelae of COVID-19 has increased largely through the rapid dissemination of information through various information platforms. In the early months of 2020, reports of a high incidence of COVID-19–related coagulopathy circulated online, with anecdotal evidence and case reports emerging initially. This was soon followed by marked increases in clinical thrombosis, including deep vein thromboses, pulmonary emboli [1,2], and microthrombi in pulmonary vasculature in postmortem pathological studies [3]. Evidence of COVID-19–associated coagulopathy disseminated rapidly online during the first months of 2020, followed by clinical debate about how best to manage thrombotic risks in these patients. The impact of global online search trends and online discussion on local approaches to coagulopathy in patients with COVID-19 has not been studied
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