Abstract
ABSTRACTIn this paper, we have developed inverted photothermal lens microscopy (PTLM) with a flow through optical cell for online detection of gold nanoparticles (AuNPs) to monitor the AuNP production process and aggregation. The indirect detection of the plasmonic signals of AuNPs was performed using the thermal lens phenomena. The measurements were made using continuous-wave excitation (532 nm) and probe laser beams (652 nm). The changes of the transmitted probe beam’s intensity were detected with a photodiode. The results show the possibility of online determination of AuNPs in micro and nanovolumes in the range of 1.7–13.7 particles for the focal volume of the excitation beam. The obtained limit of detection and relative standard deviation for 10 repeated measurements of AuNPs were 0.65 nM and 1.43%, respectively. Therefore, this system was successfully applied for screening of aggregation in process applications.
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