Abstract
The present study was carried out to investigate the effectiveness of three plant parts methanol extracts (orange peel extract, OPE, red onion skin powder, ROSE, and prickly pear extract, PPE) mixed with beef meatballs in modulating hyperglycemia using alloxan induced diabetic rats model. Treatment of animals with alloxan caused a significant increase (p≤0.05) in serum glucose concentration (49.47%) compared to normal control group. Compared to the diabetic control, hypoglycemic capability of beef meatballs supplemented with 0.1% plant parts methanolic extracts was demonstrated by significant (p≤0.05) decreasing of glucose concentration in serum. The rate of decreasing was recorded 29.91, 39.99, 31.15 and 41.75% for meatballs supplemented with OPE, ROSE, PPPE and their mixture, respectively. The same behavior was recorded for liver tissue malonaldialdehyde (MDA) level, the biomarker of oxidative stress in liver. Activities of AST, ALT and ALP were increased significantly (P<0.05) in alloxan-induced diabetic rats in comparison with normal control group. Treatment with meatballs mixed with selected methanolic extracts to diabetic rats significantly (P < 0.05) decreased the elevated AST, ALT and ALP almost near to normal levels. In conclusion, OPE, ROSE and PPPE have ameliorated the effect of alloxan induced diabetes in rats. So, we advise to use these plant parts extracts in human nutrition as natural food additives for their anti-hyperglycemic effects.
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