Ongoing electroencephalographic rhythms related to exploratory movements in transgenic TASTPM mice

Abstract

AbstractBackgroundThe European PharmaCog study (www.pharmacog.org) has reported a reduction in delta (1‐6 Hz) electroencephalographic (EEG) power (density) during cage exploration (active condition) compared with quiet wakefulness (passive condition) in PDAPP mice (hAPP Indiana V717F mutation) modeling Alzheimer’s disease (AD) amyloidosis and cognitive deficits. Here, we tested under similar conditions a cohort of TASTPM mice, in order to assess the reproducibility of the results, the studies were conducted in four different research centers of the PharmaCog consortium.MethodOngoing EEG rhythms were recorded from a frontoparietal bipolar channel in 29 TASTPM and 58 matched “wild type” C57 mice (range of age: 12‐24 months). Normalized EEG power was calculated. Frequency and amplitude of individual delta and theta frequency (IDF and ITF) peaks were considered during the passive and active conditions.ResultCompared with the “wild type” group, the TASTPM group showed a significantly lower reduction in IDF power during the active over the passive condition (p<0.05). This effect was observed in 3 out of 4 EEG recording centersConclusionTASTPM mice were characterized by “poor reactivity” of delta EEG rhythms during the cage exploration in line with previous evidence in PDAPP mice. The reliability of that result across the centers was moderate, thus motivating the use of EEG biomarkers in future multicenter preclinical trials performed in TASTPM mice.