One-year survival rate of patients with primary malignant central nervous system tumors after surgery in Kazakhstan.

Yevgeniy Zhukov,Nurgul Aldiyarova,Raushan Auezova,Nurzhan Ryskeldiyev,Zauresh Akhmetzhanova,Nurbek Igissinov,Serik Akshulakov

doi:10.7314/apjcp.2014.15.16.6973

Yevgeniy Zhukov, Nurgul Aldiyarova + Show 5 more

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https://doi.org/10.7314/apjcp.2014.15.16.6973

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Abstract

This study was conducted to evaluate the one-year survival rate of patients with primary malignant central nervous system (CNS) tumors after surgical treatment in Kazakhstan. Retrospective data of patients undergoing operations in the Department of Central Nervous System Pathology in the JSC National Centre for Neurosurgery in the period from 2009 to 2011 were used as the research material. Kaplan-Meier survival analysis was performed with the following information: gender, date of birth, place of residence, diagnosis according to ICD- 10, the date of the operation, the morphological type of tumor, clinical stage, state at the end of the first year of observation, and the date of death. The study was approved by the ethical committee of the JSC National Centre for Neurosurgery. The overall one-year overall survival rate (n=152) was 56.5% (95% confidence interval (CI): 50.2-62.7), and 79.5% (95% CI 72.2-86.8) and 33.1% (95% CI: 21.0-42.3) for Grades I-II (n=76) and Grades III-IV (n=76), respectively. Significant prognostic factors which affected the survival rate were age and higher tumor grade (Grades III-IV), corresponding with results described elsewhere in the world.

Highlights

According to the International Agency for Research on Cancer GLOBOCAN, the incidence rate of brain and central nervous system tumors worldwide in 2012 was equal to 256,213 or 3.4% per 100,000
Primary malignant brain tumors accounted for only 2% of all cancers and were one-fifth as common as breast cancer or lung cancer, they contributed to significant morbidity, and their prognosis was very poor
The 5-year relative survival rates varied considerably according to the histological subtypes, for example 79.1% for oligodendrogliomas, 27.4% for anaplastic astrocytomas and 4.5% for glioblastomas (CBTRUS 2010)

Summary

Introduction

According to the International Agency for Research on Cancer GLOBOCAN, the incidence rate of brain and central nervous system tumors worldwide in 2012 was equal to 256,213 or 3.4% per 100,000. Incidence rate by gender was 22.3 in women and 18.8 in men per 100,000 (Dolecek et al, 2012). The 5-year survival rate for primary malignant brain tumors in 1999-2005 was 36% and was the sixth or the lowest among all types of cancer as pancreas, liver, esophagus, lung and stomach (American Cancer Society, 2010). Age-specific mortality rates for brain tumors demonstrated gradual increase with each decade of age up to 55 years, after which there was a sharp increase in rates (Daroff et al, 2012). According to the SEER 2010 (Survival, Epidemiology, and End Results), primary malignant tumors of CNS (PMT CNS) incidence rate was 7.5 per 100,000 in men and 5.2 per 100,000 in women (Altekruse et al, 2010)

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