Abstract
An ideal hernia mesh is one that absorbs drugs and withstands muscle forces after mesh implantation. Polypropylene (PP) mesh devices have been accepted as a standard material to repair abdominal hernia, but the hydrophobicity of PP fibers makes them unsuitable to carry drugs during the pre-implantation of PP meshes. In this study, for the first time, one-step functionalization of PP mesh surfaces was performed to incorporate bio-inspired polydopamine (PDA) onto PP surfaces. All PP mesh samples were dipped in the same concentration of dopamine solution. The surface functionalization of PP meshes was performed for 24 h at 37 °C and 80 rpm. It was proved by scanning electron microscopic (SEM) images and Fourier Transform Infrared Spectroscopy (FTIR) results that a thin layer of PDA was connected with PP surfaces. Moreover, water contact angle results proved that surface functionalized PP meshes were highly hydrophilic (73.1°) in comparison to untreated PP mesh surfaces (138.5°). Thus, hydrophilic PP meshes with bio-inspired poly-dopamine functionalization could be a good choice for hernia mesh implantation.
Highlights
A hernia is a defect in the abdominal wall due to the “protrusion” of an organ [1,2]
PP meshes were surface functionalized with bio-inspired polydopamine (PDA)
PP fibers. with PDA and many hydrophilic groups (OH) are present on the surfaces of Polypropylene mesh devices were successfully surface functionalized with polydopamine (PDA)
Summary
A hernia is a defect in the abdominal wall due to the “protrusion” of an organ [1,2]. Repair of the hernia is a common practice to reinforce the operated muscles of the hernia to their original place with biomaterial [3]. It is reported that standard PP mesh is not suitable for hernia repair due to the reason that pre-operative prophylaxis during mesh implantation has failed [17,18,19]. Considering the surface properties of chemically inert PP fibers and self-polymerization properties of bio-inspired poly-dopamine, it was our objective to surface functionalize the PP surfaces using poly-dopamine (PDA) without changing the bulk properties of PP mesh fibers. PP mesh materials were surface functionalized with PDA at room temperature. The surface wettability of PDA treated PP meshes was dramatically increased in comparison to un-treated PP meshes
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