One-Step Fabrication of Electrochemical Reduced Graphene Oxide-Carboxyl Functionalized Multiwalled Carbon Nanotubes Film and Its Use as a Platform for Determination of Clopidogrel Bisulfate

Abstract

In this work, one-step fabrication of electrochemical reduced graphene oxide-carboxyl functionalized multi-walled carbon nanotubes (ErGO-[Formula: see text]MWCNTs) was successfully presented using potentiostatic method (PM). Characteristics of nanocomposite film were studied by using scanning electron microscopic (SEM) and electrochemical experiments. Furthermore, nanocomposite film of ErGO-[Formula: see text]MWCNTs was presented to develop a sensitive voltammetric sensor for detection of clopidogrel bisulphate (CLP). Electrochemical tests showed that nanocomposite film of ErGO-[Formula: see text]MWCNTs modified electrode can effectively increase currents to the oxidation of CLP due to the large accessible surface area as well as its excellent conductivity. Under optimum conditions, response peak currents were linear related to CLP in the range of [Formula: see text] to [Formula: see text] with a lower detection limits of [Formula: see text] ([Formula: see text]). Moreover, the proposed method exhibited an excellent selectivity, stability, reproducibility and was applied successfully for determination of CLP content in tablet dosage form with acceptable recovery values.