Abstract
AbstractA “one‐shot” cross coupling between benzyl alcohols and alkenyl halides has been established. A combination of low‐valent Ti‐mediated C−OH homolysis and the prominent chemistry of Ni‐based radical catalysis afforded the desired cross‐coupled product with good efficiency. The reaction proceeded regardless of the electronic property of benzyl alcohols, and Ar−B bond remained intact throughout the reaction. Alkenyl bromides with various substitution patterns were applicable to this reaction. Attempts for utilizing sterically demanding tri‐substituted alkenes indicated that the steric hinderance mainly inhibited the radical‐trapping by Ni species. This reaction can be a simple and efficient strategy for synthesizing densely substituted allylbenzene derivatives.magnified image
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
