Abstract
Abstract Novel tri-component composite microspheres of polyvinyl alcohol-silica-hydroxyapatite (PVA/SiO2/HA) were prepared in a water-in-oil emulsion. The SEM results showed that the as-prepared composite microspheres with an average diameter of 23.1 μm exhibited a regular spherical shape and a high dispersity. Their inorganic phases were identified as low-crystallized hydroxyapatite and amorphous SiO2. Moreover, the PVA/SiO2/HA composite microspheres presented an enhanced capacity for both loading and sustained release of vancomycin hydrochloride (VH) as compared to their bi-component equivalents (PVA/SiO2 and PVA/HA composite microspheres), suggesting their good potential to be used as a drug carrier in bone tissue engineering.
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