Abstract
A simple and efficient, one-pot approach for the synthesis of ether-linked diisoxazole derivatives has been developed through sequential reactions, which includes O-propargylation of 2-bromohomoallylic alcohols with propargyl bromide in the presence of sodium hydride in THF, and 1,3-dipolar cycloaddition by the addition of hydroximinoyl chlorides and triethylamine. This protocol provides some advantages such as high regioselectivity, easy operation and good product yields with a wide scope of substrates under mild conditions.
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