One-pot Synthesis of New Category of 2-aryl-quinazolinones Using of DSDABCO as an Efficient Heterocyclic Medium

Abstract

A series of 2-aryl-quinazolin-4(1H)-ones have been synthesized in short reaction times and excellent yields through one-pot reaction between isatoic anhydride, glycine and various aldehydes in the presence of DSDABCO (1,4-disulfo-1,4-diazoniabicyclo[2.2.2] octane chloride) as an efficient heterocyclic ionic liquid media at room temperature. This method offers many advantages such as green environment, mild conditions, excellent efficiency, simple method and reduction of environmental consequences. Using recyclable ionic liquid and no need to another solvent or catalyst is an important step in green chemistry. On the other hand, this method does not require heating and is done at room temperature. The ionic liquid was recovered and reused. To the best of our knowledge, this is the first report for the synthesis of a new library of quinazolin-4(1H)-ones derived from glycine as a natural substrate based on green chemistry conditions. The structures of 2-aryl-quinazolin-4(1H)-ones were confirmed by 1H, 13CNMR, HRMS and FTIR spectral data and elemental analyses.