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https://doi.org/10.1021/acs.orglett.3c01192
Copy DOIJournal: Organic Letters | Publication Date: May 18, 2023 |
Citations: 6 |
An efficient synthesis of benzo[c]phenanthridine alkaloids via a synergistic combination of C-C bond formation and a cycloaromatization reaction is described. Aryl nitrones react with 7-azabenzonorbornadienes in the presence of a Rh(III) catalyst, providing pharmaceutically useful benzo[c]phenanthridine derivatives in good to moderate yields. Using this methodology, highly useful alkaloids such as norfagaronine, norchelerythrine, decarine, norsanguinarine, and nornitidine were prepared in a single step.
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