Abstract
The one-pot synthesis of new derivatives of 2(1H)-pyridone heterocycles carrying a thiophene nucleus is described. The reactions were carried out via the condensation of 3-acetyl2,5-dichlorothiophene and different alkyl aldehydes 2a-f with ethyl cyanoacetate in presence of ammonium acetate. The pyridone derivatives 3a-f were obtained in 63-86% yields and short reaction times. The antimicrobial activities of the new compounds were evaluated against some common Gram negative and Gram positive bacteria and fungi.
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