One-pot multicomponent click synthesis of pyrazole derivatives using cyclodextrin-supported capsaicin nanoparticles as catalyst

Abstract

Facile and efficient methodology for one-pot multicomponent click synthesis of pyrazole derivatives by using phenyl hydrazine, malononitrile and varying degrees of substituted aldehydes has been described. As a recyclable heterogeneous catalyst, we used CPS-CDMNPs. The nanoparticles were prepared by two-step synthesis using co-precipitation and ultrasonication method for the synthesis of CDMNPs, and further capsaicin was deposited on CDMNPs by wet impregnation method. The catalyst can be recovered in a facile manner from the reaction mixture magnetically by applying magnet outside the flask. Moreover, this protocol features the shortest reaction time, simple procedure, high conversion and no tedious workup procedures.