Abstract
ABSTRACT. One-pot, mild and efficient synthesis of various spiro-nitrogen heterocycle compounds, based on the reaction of ninhydrin and 1,2-diamino-benzene, (indenoquinoxalin), with N-heterocycle compounds and dialkylacetylenedicarboxylates is described. Using this approach, various spiro-nitrogen heterocycle compounds at a temperature of 50-60 °C in acetonitrile solvent, can be obtained very high yields.
 
 KEY WORDS: Ninhydrin, 1,2-Diaminobenzene, spiro-Nitrogen heterocycle compounds, Indenoquinoxalin, N-heterocycle compounds, Dialkylacetylenedicarboxylates
 
 Bull. Chem. Soc. Ethiop. 2023, 37(1), 115-122. 
 DOI:https://dx.doi.org/10.4314/bcse.v37i1.10
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