One-pot asymmetric synthesis of α-trifluoromethylated amines from α-trifluoromethyl ketones

Abstract

Diastereoselective reduction of ( Rs)- N- tert-butanesulfinyl α-trifluoromethyl ketimines formed in situ from the corresponding α-trifluoromethyl ketones and N- tert-butanesulfinamide has been achieved, and either diastereomer of N- tert-butanesulfinyl α-trifluoromethyl amines was obtained in good yields with excellent diastereoselectivities (up to 99:1 dr) using NaBH 4 and L-Selectride as the reductants, respectively.