Abstract
ObjectiveDifferentiation of atypical adenomatous hyperplasia (AAH), bronchioloalveolar carcinoma (BAC), and invasive carcinoma on computed tomography (CT) is useful for determining “follow-up or resection” strategies for lesions displaying ground-glass opacity (GGO). The purpose of this study is to evaluate one-dimensional quantitative CT values of GGO on high-resolution CT (HRCT) images using computer-aided diagnosis.MethodsBetween April 2001 and March 2010, a total of 44 nodules in 42 patients with pure or mixed GGOs ≤2 cm were retrospectively evaluated. Maximum diameter and one-dimensional mean CT (m-CT) value of the diameter were measured using a computer graphics support system (HOPE/DrABLE-EX, Fujitsu, Tokyo, Japan) that displays a CT density profile across the tumor.Resultsm-CT values were −682 ± 64 HU (range) for AAH lesions, −544 ± 179 (range) for Type A lesions, −496 ± 147 (range) for Type B lesions, and −371 ± 142 (range) for invasive lesions. AAH lesions had a significantly lower m-CT value than Type B lesions. AAH, Type A, and Type B lesions had significantly lower m-CT values than invasive lesions (p < 0.05). All seven GGO lesions with a maximum diameter ≤1 cm and m-CT value ≤−600 HU were pre-invasive lesions, while 16 of 22 (73 %) cases with maximum diameter >1 cm and m-CT value >−600 HU were invasive lesions.ConclusionObservation may be indicated for GGO lesions with a maximum diameter ≤1 cm and m-CT value ≤−600 HU.
Highlights
Recent advances in computed tomography (CT) scanning technology have enabled the detection of many lung cancers, adenocarcinoma, at an earlier and potentially more curable stage than was previously possible [1]
Observation may be indicated for ground-glass opacity (GGO) lesions with a maximum diameter B1 cm and mean CT (m-CT) value B-600 Hounsfield units (HU)
The purpose of this study is to evaluate the one-dimensional quantitative CT value of GGO on high-resolution CT (HRCT) images using computer-aided diagnosis to retrospectively select ‘‘follow-up or resection’’ strategies for GGO
Summary
Recent advances in computed tomography (CT) scanning technology have enabled the detection of many lung cancers, adenocarcinoma, at an earlier and potentially more curable stage than was previously possible [1]. The true clinical significance of small tumors found through screening is unknown, as no differences in mortality between screened and unscreened individuals have been observed [2, 3]. Treatment strategies for small tumors displaying ground-glass opacity (GGO) remain controversial. The purpose of this study is to evaluate the one-dimensional quantitative CT value of GGO on high-resolution CT (HRCT) images using computer-aided diagnosis to retrospectively select ‘‘follow-up or resection’’ strategies for GGO
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have