Abstract
BackgroundCentral serous chorioretinopathy (CSC) is characterized by an accumulation of subretinal fluid (SRF) in the macula. It is usually treated by laser photocoagulation or photodynamic therapy (PDT) with consisting of different doses and power. This study aimed to compare the efficacy of half-dose PDT and one-third-dose PDT in chronic or recurrent CSC.MethodsA retrospective review of patients with chronic or recurrent CSC who were treated with either a half-dose or one-third-dose PDT, and had follow up 12 months afterwards. Best-corrected visual acuity (BCVA), central retinal thickness (CRT) and resolution of subretinal fluid (SRF) at baseline as well as 1, 3, 6 and 12 months post-PDT were assessed.ResultsForty-six eyes and 20 eyes received half-dose and one-third-dose PDT, respectively. The study showed efficacy of the one-third-dose PDT compared with half-dose PDT in BCVA improvement (0.10±0.04 logMAR for one-third-dose versus 0.17±0.04, for half-dose, P=0.148) and CRT improvement (125.6±24.6 μm for one-third-dose versus 139.1±16.54, for half-dose, P=0.933) at 12 months. The SRF recurrence rate was significantly higher in the one-third-dose PDT group compared with the half-dose PDT group (40.0% versus 15.2%, P=0.027) at 12-months.ConclusionAt 12 months, the one-third-dose PDT was effective in terms of BCVA and CRT improvement, when compared with half-dose PDT. However, this study showed that one-third-dose PDT had a higher recurrence rate of SRF.
Highlights
Central serous chorioretinopathy (CSC) is characterized by an accumulation of subretinal fluid (SRF) in the macula
A brief summary statement At 12 months, the one-third-dose Photodynamic therapy (PDT) was effective in term of Best-corrected visual acuity (BCVA) and central retinal thickness (CRT) improvement, when compared with half-dose PDT
This study showed that the one-third-dose PDT had a higher recurrence rate of SRF
Summary
Central serous chorioretinopathy (CSC) is characterized by an accumulation of subretinal fluid (SRF) in the macula. It is usually treated by laser photocoagulation or photodynamic therapy (PDT) with consisting of different doses and power. Post-PDT complications, such as RPE change, choroidal ischemia and secondary CNV [14,15,16], have motivated studies of the effect of lowering the dose of verteporfin, or decreasing the laser power energy (decreasing the fluence), so as to minimize post-PDT complications. Many studies have reported the efficacy of half-dose PDT and half-fluence PDT in treatment of acute and chronic CSC, without serious complications [17,18,19,20,21,22,23]
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