Abstract
Results: Neointimal area in the HIGH group (0.30±0.06) was lower than in the BARE (0.45±0.17), the POL (0.58±0.42), and the LOW (0.56±0.27) groups (Pb.05). Accordingly, percentage stenosis in the HIGH group (16.9±4.2%) was lower than in the BARE (21.8±6.2%), LOW (33.6±16.3%), and POL (27.3±15.1%) groups, respectively. No significant differences were observed in inflammation, angiogenesis, and hemorrhage and fibrin between the BARE and HIGH groups. Representative histological section of a high-dose stent is presented in the image. Conclusion: Retinoic acid-eluting stent reduced neointimal area by 33% and percentage stenosis by 22% compared to bare cobalt chromium stents while showing no differences in inflammation and angiogenesis in the rabbit iliac artery model. RA appears to be a promising noncytotoxic substance for a new generation of drug-eluting stents. Further research is needed in order to establish the long-term efficacy.
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