Abstract

1. An experimental study investigated the effects of intermittent hypoxia (IH) on thoracic aortic dissection (TAD) development in a mouse TAD model induced by β-aminopropionitrile monofumarate (BAPN) and showed an alleviation by IH. According to the results of this study, which of the following is correct? 1A)IH exposure reduced BAPN-induced elastin breaks.B)IH exposure reduced BAPN-induced elastin breaks and apoptosis of vascular smooth muscle cellsC)IH exposure reduced BAPN-induced apoptosis of vascular smooth muscle cellsD)IH exposure failed to reverse BAPN-induced extracellular matrix (ECM) degradation, indicating that ECM plays a minor role in the pathophysiology of TAD in mice.E)None of the above

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