Abstract

1. Based on previous knowledge indicating that pan-phosphatidylinositol 3-kinease (PI3K) inhibitor treatment could suppress formation of experimental abdominal aortic aneurysms, what is the importance of studying the role of PI3Kγ in AAAs?1A.PI3K is significantly involved in regular cellular functions and systemic inhibition of PI3K has severe side effects.B.PI3Kγ mainly expressed in infiltrated lymphocytes, which plays a pivotal role in AAAs formation.C.PI3Kγ prevents formation of AAAs.D.PI3Kγ leads to formation of AAAs.E.The role of PI3Kγ in formation of AAAs is not essential.

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