Abstract
One-Year Mortality in Patients with Community-Acquired Pneumonia
Highlights
Pneumonia remains a common cause of morbidity and mortality in the US
We examine the current knowledge of long-term mortality and propose a hypothesis explaining the pathogenesis of long-term mortality in patients with communityacquired pneumonia (CAP)
Improving the clinical outcomes of hospitalized patients with CAP is of paramount importance for patients, as well as clinical investigators
Summary
Pneumonia remains a common cause of morbidity and mortality in the US. Published data from the Centers for Disease Control and Prevention ranks pneumonia as the first leading cause of death from infectious diseases and eight from all diseases [1]. Mortality rates range from 4 - 30% depending on the studied population, treatment setting, and severity of disease [5,6,7,8] Considering this short-term impact on patients’ outcomes, CAP research has been traditionally focused on improving short-term outcomes such as time to clinical stability, clinical failure, length of stay, in-hospital mortality, and 30-day mortality. Data have emerged showing that patients surviving an episode of CAP are at increased risk of death long after hospital discharge [13,14,15,16,17,18,19,20,21,22,23,24,25,26]. In an attempt to standardize the follow-up period, we only included in this review original studies that either reported mortality at 1 year or had enough data to estimate this information
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