One Year Analysis of Hematological and Inflammatory Parameters to Predict the Severity of COVID-19 Infection in Pregnant Women

Abstract

Objective: The study aims to demonstrate the usability of admission hematological parameters in the prognosis of COVID-19 infection in pregnant population and to introduce the cut-offs values of these parameters for pregnant women.Methods: The cohort of this retrospective study consisted of 71 COVID-19 PCR positive pregnant women who were hospitalized in Ordu University Medical Faculty Training and Research Hospital between 1 May 2020 and 1 May 2021. The pregnant women were divided into two groups based on the severity of the disease.Results: White blood cell count, neutrophil count and C-reactive protein (CRP) levels was significantly higher (p=0.000, p=0.000), whereas red blood cell count and lymphocyte count were significantly lower (p=0.002, p=0.002) in severe group. High NLR (neutrophil-to-lymphocyte ratio) (p=0.000), dNLR (derived neutrophil-to-lymphocyte ratio) (p=0.000), MLR (monocyte-to-lymphocyte ratio) (p=0.004), PLR (platelet-to-lymphocyte ratio) (p=0.008), NPR (neutrophil-to-platelet ratio) (p=0.005), NLRNPR (neutrophil-to-lymphocyte ratio/neutrophil-to-platelet ratio) (p=0.008) and SII (Systemic immune inflammation index) (p=0.000) were found in severe group.Conclusion: This paper revealed that severe COVID-19 disease in pregnant women is mainly associated with hematological parameters. Among these parameters NLR, dNLR and SII have largest AUC in ROC, with cutoff values 5.3, 3.52 and 994.8 respectively. Further investigations regarding the use of hematologic tests as prognostic factor of COVID-19 disease severity in pregnant women are needed to assess the risk of serious disease, to predict the prognosis of COVID-19 and to reduce perinatal and maternal morbidity/mortality.