Abstract
Effective flux of steroid solute through skin can be achieved by the use of ethanol as a co-solvent and penetration enhancer. To maintain constant drug release from a reservoir-type transdermal device and permeation through the skin, the composition of ethanol in the reservoir must remain constant. Ethanol permeability is much higher than that of either drug or water; any decrease in ethanol content may result in decreased drug flux. In an attempt to design a transdermal delivery device with constant ethanol enhancing activity, a model system was designed with separate ethanol reservoir, drug/solvent reservoir and receiver compartments. The ethanol and drug/solvent reservoir compartments were separated by a polydimethylsiloxane copolymer laminate membrane. This ‘one-way’ rate-controlling membrane (Yuk et al., Int. J. Pharm., 77 (1991) 221–229) optimized ethanol flux while preventing drug and water back flux. Permeation studies with model steroid solutes in this system demonstrated consistent ethanol enhancing activity with constant solute flux across the skin.
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