Abstract
The effect of calcitonin on the blood glucose level in glucose-tolerance test of children with the first degree obesity was studied. Initial blood glucose level was normal and glucose-tolerance test per os didn’t expose glucose tolerance impairment in children under control. Calcitonin didn’t change initial glucose concentration but evoked impairment of glucose tolerance. The girls with the first degree obesity were more sensitive to hyperglycemic effect of calcitonin than the boys. Sex specificities must be taken into consideration in calcitonin treatment. Besides one ought mean that the increasing secretion of calcitonin occurs in stress-reactions. In these conditions endogenous calcitonin can make the same effect on the regulation of carbohydrate metabolism as exogenous injections of hormone.
Highlights
It is known that human health is formed in early childhood, when the cause for future diseases can be established, including the metabolic syndrome and diabetes, the main factor in the development of which is the child’s excess weight, obesity is strongly associated with postnatal growth
An increased body mass index at 10 years and obesity in childhood are risk factors for the subsequent development of mellitus type I diabetes [2], and a moderate decrease in body weight significantly reduces the incidence of the metabolic syndrome [3]
This metabolism disturbance accompanies by the increasing of organism need in insulin and intensified functioning of islet’s apparatus leading to the following exhaustion. Proceeding from these conceptions it is admitted suppose that under obesity calcitonin excess can do a diabetogenic effect sooner than under normal metabolism state. In this connection the aim of our investigation was to study the effect of one-time injection of calcitonin on glucose tolerance in children with the 1st degree obesity
Summary
It is known that human health is formed in early childhood, when the cause for future diseases can be established, including the metabolic syndrome and diabetes, the main factor in the development of which is the child’s excess weight, obesity is strongly associated with postnatal growth. An increased body mass index at 10 years and obesity in childhood are risk factors for the subsequent development of mellitus type I diabetes [2], and a moderate decrease in body weight significantly reduces the incidence of the metabolic syndrome [3]. With the number of factors predisposed to diabetes mellitus belongs, as it is known, obesity This metabolism disturbance accompanies by the increasing of organism need in insulin and intensified functioning of islet’s apparatus leading to the following exhaustion. Proceeding from these conceptions it is admitted suppose that under obesity calcitonin excess can do a diabetogenic effect sooner than under normal metabolism state. In this connection the aim of our investigation was to study the effect of one-time injection of calcitonin on glucose tolerance in children with the 1st degree obesity
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