Abstract
In the UK Flexible Sigmoidoscopy Screening Trial (UKFSST), 170,000 patients (age range, 55–64) were randomized to once-only flexible sigmoidoscopy or no colorectal cancer (CRC) screening; 71% of those assigned to sigmoidoscopy actually underwent screening. After 11 years of follow-up, participants who underwent sigmoidoscopy had significant relative reductions in distal and total CRC (hazard ratios, 0.50 and 0.67, respectively) and CRC-related mortality (HR, 0.57) compared with participants randomized to no screening (NEJM JW …
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