Abstract
A transition‐metal‐free synthetic protocol involved with trifluoromethyl radical addition–cyclization of 2‐(allyloxy)arylaldehydes for a series of CF3‐containing 3‐substituted chromenones formation has been developed. The radical cascade cyclization–coupling reaction can be run in a one‐step manner with Langlois′ reagent (CF3SO2Na) and K2S2O8. Broad scopes of substrates with various functional groups are evaluated in moderate to good efficacy under operational simplicity and mild reaction conditions. A plausible mechanism for the construction of trifluoroethylated chromones is proposed based on mechanistic studies.
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