Abstract
AbstractIsonitrile‐functionalized biaryl ethers can serve as key building blocks for the highly efficient one‐step production of natural product inspired‐macrocycles, with six or even twelve new bonds and rings with up to 50 members being formed in total yields of up to 51 %. Aliphatic diamine and diacid tethers give access to two different classes of N‐substituted biaryl ether cyclopeptides, suitable for library construction. As part of a conceptual work on MiBs (multiple multicomponent macrocyclizations/macrocycles including bifunctional building blocks), the influence of length and type of flexible tethers on the propensity for cyclization is studied.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
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