One-step synthesis of 4(3 H)-quinazolinones

Abstract

2-Fluoro substituted benzoyl chlorides undergo cyclocondensation with 2-amino- N-heterocycles to form 4(3 H)-quinazolinones. The reaction proceeds in moderate yields with different combinations of benzoyl chlorides and 2-amino- N-heterocycles. The products generally precipitate from the reaction mixture and require no further purification. Two tetrafluoro quinazolinones were found to be moderately active against a number of tumor cell lines.