Abstract

The first tandem cross-coupling/oxa-Michael addition/dehydrogenation process via rhodium chemistry is described, which provides a straightforward and atom-economical protocol for the synthesis of a wide range of valuable γ-alkylidenebutenolides. This method is of particular interest because of employing widely available and low cost vinyl carboxylic acids and electron-deficient alkenes as building blocks. Moreover, the methodology can be applied to a gram scale synthesis with 1 mol% catalyst loading.

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