Abstract
Dental implants can fail due to various factors, in which bad tissue integration is believed to have a significant role. Specific properties of the implant surface, such as its chemistry and roughness, are of paramount importance to address specific cell responses, such as the adsorption of proteins, as well as the adhesion and differentiation of cells, which are suitable for biomaterial and tissue engineering. In this study, an acrylate-containing coating was produced on titanium surfaces through the atmospheric pressure plasma treatment of a liquid precursor, 2-hydroxyethyl methacrylate. A hydrophilic coating was obtained, showing retention of the monomer chemistry as assessed by FTIR analysis and XPS. Enhanced fibroblast adhesion and decreased Staphylococcus aureus and Escherichia coli adhesion were recorded, showing that this is a suitable method to produce biocompatible coatings with a reduced bacterial adhesion.
Highlights
Due to a static plasma treatment and the local confinement of the area that was directly exposed to the plasma, the contact angles were measured on two different positions: one in the center of the coating and the other one in the edge region of the coating
A plasma-polymerized, hydroxyethyl methacrylate (HEMA)-based coating has been successfully prepared by treating the liquid monomer with an atmospheric pressure plasma jet
The coating showed retained wettability and chemical composition compared with the precursor
Summary
Dental implants are a common solution to overcome the problem of tooth loss [1]. These implants can fail due to various factors, in which the lack of osseointegration—the ingrowth of the implant into the bone structure—and implant-related infections are thought to play a key role [2,3,4,5]. Specific properties of the implant surface, such as chemistry and roughness, play a determining role to address specific cell responses (e.g., the adsorption of proteins, as well as the adhesion and differentiation of cells) suitable for biomaterial and tissue engineering. Various attempts have been made to increase the success rate of implants by tailoring the surface properties, including modification of the topography features [11], doping with inorganic antimicrobial agents [12,13,14,15,16,17,18], immobilizing bioactive molecules like antibiotics [19,20] or peptides [21,22,23,24,25,26,27] and coating the titanium surface with polymers [28,29,30,31]
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