Abstract
A simple and economical hydrothermal strategy was developed for the synthesis of nitrogen-doped graphitic quantum dots (N-GQDs) using citric acid as carbon source and melamine as nitrogen source. The as-synthesized N-GQDs possess many excellent features, such as strong blue fluorescence, excitation-independent emission, high monodispersity, good stability, and excellent water solubility with a fluorescence quantum yield of 18%. The analytical application of this method as an effective sensor for direct analysis of metacycline (MTC) revealed its selective response via a fluorescence quenching mechanism. This sensing system exhibits excellent sensitivity and selectivity toward MTC with the detection limit of 20nM, which was successfully applied in the detection of MTC in mice plasma.
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