Abstract
In this work we have developed an analytical method to measure potential titanium debris released from TiO2 nanotube layers devices immersed in biological fluids. This quantitative study is highly required to ensure both the security and non toxicity of the nanostructured surfaces used as future implantable medical devices in the living. A one-pot synthesis process is developed to produce high quality standard solutions of titanium dioxide nanoparticles in aqueous medium. The elaborated dispersion is then used to fabricate standard solutions in both aqueous and human blood plasma media. The synthesized nanoparticles dispersion was characterized by granulometry. The nanoparticles structure and morphology were then observed using Transmission Electron Microscopy (TEM). Thermogravimetric Analysis (TGA) was used to evaluate the concentration of TiO2 in the suspension. A quantitative routine by the use of Inductively Coupled Plasma Atomic Emission Spectroscopy (ICP-AES) is developed. The quantification threshold of titanium species is found to be in the 30 - 40 ppb range. None interference is detected between the particles and the human blood plasma. Using the established quantitative routine, the titanium species release from titania nanotube layers in human blood plasma is evaluated.
Highlights
Nanotextured materials with the required surface properties are promising candidates to develop the implantation of new kind of biocompatible platforms in the living
Functionalized crystalline TiO2 nanoparticles in suspension have been synthesized by a derivated sol-gel process at low temperature
In order to cope with this key problem of the required stability of the standard solution, we used a one-pot synthesis of TiO2 nanoparticles dispersion in an aqueous medium
Summary
Nanotextured materials with the required surface properties are promising candidates to develop the implantation of new kind of biocompatible platforms in the living. Works need to be done in order to ensure the biological security of such future nanostructured medical devices implanted in the living [14]. We develop a quantitative method to measure possible metallic debris released from the use of TiO2 nanotube layers as future nanostructured medical implants. This quantitative method using Inductively Coupled Plasma Atomic Emission Spectroscopy (ICP-AES) requires well defined TiO2 standard solutions commercially unavailable. Nanotube layers samples were immersed in human blood plasma under magnetic stirring at 37 ̊C, and the titanium species concentration in the liquid is followed by the established quantification method
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